Fall of the Muromachi Shogunate
Also called: Siege of Makishima, End of the Ashikaga shogunate
The shogun Ashikaga Yoshiaki took up arms against Oda Nobunaga, surrendered at Makishima Castle and was driven out of Kyoto. The Muromachi shogunate, after more than 230 years, effectively came to an end.

Published by Meguro Shoten (目黒書店) · Public domain · Source
Having fallen out with Nobunaga, Yoshiaki tried to encircle him with Takeda Shingen, the Asakura and Azai, the Hongan-ji and others. When Shingen marched west in 1572 and beat the Tokugawa at Mikatagahara, Yoshiaki rose in 1573, but his plans collapsed when Shingen died of illness on campaign that spring.
In August 1573 Nobunaga attacked Makishima Castle at Uji, forced Yoshiaki to surrender and expelled him from Kyoto. The era name was changed to Tenshō, and Nobunaga soon destroyed the Asakura and Azai as well. Yoshiaki kept the title of shogun at Tomo in Bingo under the protection of the Mōri and gave it up only in 1588, so some date the end of the shogunate to 1588 rather than 1573.